Next Article in Journal
Kaxiras’s Porphyrin: DFT Modeling of Redox-Tuned Optical and Electronic Properties in a Theoretically Designed Catechol-Based Bioinspired Platform
Previous Article in Journal
Cell-Adhesive Bioinspired and Catechol-Based Multilayer Freestanding Membranes for Bone Tissue Engineering
Previous Article in Special Issue
Protein-Mediated Biotemplating on the Nanoscale
Article Menu

Export Article

Open AccessArticle
Biomimetics 2017, 2(4), 20; doi:10.3390/biomimetics2040020

Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films

Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo 05508-000, SP, Brazil
*
Author to whom correspondence should be addressed.
Received: 10 August 2017 / Revised: 16 October 2017 / Accepted: 18 October 2017 / Published: 20 October 2017
(This article belongs to the Special Issue Biomimetic Nanotechnology)
View Full-Text   |   Download PDF [2169 KB, uploaded 23 October 2017]   |  

Abstract

The optimization of bilayer coverage on particles is important for a variety of biomedical applications, such as drug, vaccine, and genetic material delivery. This work aims at optimizing the deposition of cationic bilayers on silica over a range of experimental conditions for the intervening medium and two different assemblies for the cationic lipid, namely, lipid films or pre-formed lipid bilayer fragments. The lipid adsorption on silica in situ over a range of added lipid concentrations was determined from elemental analysis of carbon, hydrogen, and nitrogen and related to the colloidal stability, sizing, zeta potential, and polydispersity of the silica/lipid nanoparticles. Superior bilayer deposition took place from lipid films, whereas adsorption from pre-formed bilayer fragments yielded limiting adsorption below the levels expected for bilayer adsorption. View Full-Text
Keywords: AEROSIL OX-50; dioctadecyldimethylammonium bromide; N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride; elemental analysis for in situ adsorption; colloidal stability; cationic bilayer fragments; films of cationic lipids; optimal bilayer adsorption from films AEROSIL OX-50; dioctadecyldimethylammonium bromide; N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride; elemental analysis for in situ adsorption; colloidal stability; cationic bilayer fragments; films of cationic lipids; optimal bilayer adsorption from films
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ribeiro, R.T.; Braga, V.H.A.; Carmona-Ribeiro, A.M. Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films. Biomimetics 2017, 2, 20.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomimetics EISSN 2313-7673 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top