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Fermentation 2018, 4(2), 43; https://doi.org/10.3390/fermentation4020043

Micro- and Nanoscale Approaches in Antifungal Drug Discovery

1
Alliance Research Group VUB-UGent NanoMicrobiology (NAMI), IJRG VUB-EPFL NanoBiotechnology & NanoMedicine (NANO), Research Group Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium
2
Department Bioscience Engineering, University Antwerp, 2020 Antwerp, Belgium
Received: 7 May 2018 / Revised: 4 June 2018 / Accepted: 5 June 2018 / Published: 11 June 2018
(This article belongs to the Special Issue Yeast Biotechnology 2.0)
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Abstract

Clinical needs for novel antifungal agents have increased due to the increase of people with a compromised immune system, the appearance of resistant fungi, and infections by unusual yeasts. The search for new molecular targets for antifungals has generated considerable research, especially using modern omics methods (genomics, genome-wide collections of mutants, and proteomics) and bioinformatics approaches. Recently, micro- and nanoscale approaches have been introduced in antifungal drug discovery. Microfluidic platforms have been developed, since they have a number of advantages compared to traditional multiwell-plate screening, such as low reagent consumption, the manipulation of a large number of cells simultaneously and independently, and ease of integrating numerous analytical standard operations and large-scale integration. Automated high-throughput antifungal drug screening is achievable by massive parallel processing. Various microfluidic antimicrobial susceptibility testing (AST) methods have been developed, since they can provide the result in a short time-frame, which is necessary for personalized medicine in the clinic. New nanosensors, based on detecting the nanomotions of cells, have been developed to further decrease the time to test antifungal susceptibility to a few minutes. Finally, nanoparticles (especially, silver nanoparticles) that demonstrated antifungal activity are reviewed. View Full-Text
Keywords: antifungal drug discovery; microfluidics; nanobiotechnology; omics-based approaches; antifungal susceptibility testing; nanomotion detection; nanoparticles antifungal drug discovery; microfluidics; nanobiotechnology; omics-based approaches; antifungal susceptibility testing; nanomotion detection; nanoparticles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Willaert, R.G. Micro- and Nanoscale Approaches in Antifungal Drug Discovery. Fermentation 2018, 4, 43.

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