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Fermentation 2018, 4(1), 13; https://doi.org/10.3390/fermentation4010013

Biological Production of 3-Hydroxypropionic Acid: An Update on the Current Status

Biochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, SE-971 87 Luleå, Sweden
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Received: 22 January 2018 / Revised: 5 February 2018 / Accepted: 9 February 2018 / Published: 13 February 2018
(This article belongs to the Special Issue Bioconversion Processes)
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Abstract

The production of high added-value chemicals from renewable resources is a necessity in our attempts to switch to a more sustainable society. 3-Hydroxypropionic acid (3HP) is a promising molecule that can be used for the production of an important array of high added-value chemicals, such as 1,3-propanediol, acrylic acid, acrylamide, and bioplastics. Biological production of 3HP has been studied extensively, mainly from glycerol and glucose, which are both renewable resources. To enable conversion of these carbon sources to 3HP, extensive work has been performed to identify appropriate biochemical pathways and the enzymes that are involved in them. Novel enzymes have also been identified and expressed in host microorganisms to improve the production yields of 3HP. Various process configurations have also been proposed, resulting in improved conversion yields. The intense research efforts have resulted in the production of as much as 83.8 g/L 3HP from renewable carbon resources, and a system whereby 3-hydroxypropionitrile was converted to 3HP through whole-cell catalysis which resulted in 184.7 g/L 3HP. Although there are still challenges and difficulties that need to be addressed, the research results from the past four years have been an important step towards biological production of 3HP at the industrial level. View Full-Text
Keywords: 3-hydroxypropionic acid; metabolic engineering; building-block chemicals; glycerol; platform chemicals; Klebsiella pneumoniae; Escherichia coli; Saccharomyces cerevisiae 3-hydroxypropionic acid; metabolic engineering; building-block chemicals; glycerol; platform chemicals; Klebsiella pneumoniae; Escherichia coli; Saccharomyces cerevisiae
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Matsakas, L.; Hrůzová, K.; Rova, U.; Christakopoulos, P. Biological Production of 3-Hydroxypropionic Acid: An Update on the Current Status. Fermentation 2018, 4, 13.

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