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Gels 2016, 2(2), 18; doi:10.3390/gels2020018

Combinatorial Method/High Throughput Strategies for Hydrogel Optimization in Tissue Engineering Applications

1
Vivian L. Smith Department of Neurosurgery & Center for Stem Cells and Regenerative Medicine McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX 77030, USA
2
Department of Nanomedicine and Biomedical Engineering, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Academic Editor: Esmaiel Jabbari
Received: 25 March 2016 / Revised: 1 June 2016 / Accepted: 3 June 2016 / Published: 8 June 2016
(This article belongs to the Special Issue Hydrogels in Tissue Engineering)
View Full-Text   |   Download PDF [1567 KB, uploaded 8 June 2016]   |  

Abstract

Combinatorial method/high throughput strategies, which have long been used in the pharmaceutical industry, have recently been applied to hydrogel optimization for tissue engineering applications. Although many combinatorial methods have been developed, few are suitable for use in tissue engineering hydrogel optimization. Currently, only three approaches (design of experiment, arrays and continuous gradients) have been utilized. This review highlights recent work with each approach. The benefits and disadvantages of design of experiment, array and continuous gradient approaches depending on study objectives and the general advantages of using combinatorial methods for hydrogel optimization over traditional optimization strategies will be discussed. Fabrication considerations for combinatorial method/high throughput samples will additionally be addressed to provide an assessment of the current state of the field, and potential future contributions to expedited material optimization and design. View Full-Text
Keywords: tissue engineering; hydrogel; high throughput; design of experiment; array and continuous gradient tissue engineering; hydrogel; high throughput; design of experiment; array and continuous gradient
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Smith Callahan, L.A. Combinatorial Method/High Throughput Strategies for Hydrogel Optimization in Tissue Engineering Applications. Gels 2016, 2, 18.

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