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J. Fungi 2018, 4(3), 97; https://doi.org/10.3390/jof4030097

Treatment of Invasive Candidiasis: A Narrative Review

Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
Received: 25 July 2018 / Revised: 8 August 2018 / Accepted: 12 August 2018 / Published: 16 August 2018
(This article belongs to the Special Issue Treatments for Fungal Infections)
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Abstract

Invasive candidiasis occurs frequently in hospitalized patients, and is associated with high mortality rates due to delays in recognition and initiation of appropriate antifungals. Management of invasive candidiasis must take into account multiple host, pathogen, and drug-related factors, including the site of infection, host immune status, severity of sepsis, resistance and tolerance to antifungal agents, biofilm formation, and pharmacokinetic/pharmacodynamic considerations. Recent treatment directives have been shaped by the widespread introduction of echinocandins, highly potent and safe antifungals, into clinical use, as well as important changes in drug susceptibility patterns and the emergence of known and novel drug-resistant Candida species. Advances in molecular diagnostics have the potential to guide early targeted treatment of high-risk patients. View Full-Text
Keywords: Candida; invasive candidiasis; candidemia; fluconazole; echinocandin; amphotericin B Candida; invasive candidiasis; candidemia; fluconazole; echinocandin; amphotericin B
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Ben-Ami, R. Treatment of Invasive Candidiasis: A Narrative Review. J. Fungi 2018, 4, 97.

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