Next Article in Journal
The Caryopsis of Red-Grained Rice Has Enhanced Resistance to Fungal Attack
Next Article in Special Issue
Endophytic Fungi: A Source of Potential Antifungal Compounds
Previous Article in Journal / Special Issue
Restoring Waning Production of Volatile Organic Compounds in the Endophytic Fungus Hypoxylon sp. (BS15)
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessArticle
J. Fungi 2018, 4(2), 70; https://doi.org/10.3390/jof4020070

Antiplasmodial Properties and Cytotoxicity of Endophytic Fungi from Symphonia globulifera (Clusiaceae)

1
Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, 237 Yaoundé, Cameroon
2
Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon; P.O. Box 812, 237 Yaoundé, Cameroon
3
Department of Chemistry, Faculty of Science, University of Bamenda, P.O. Box 39, 237 Bambili, Cameroon
4
Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, D-33501 Bielefeld, Germany
5
International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
6
Departamento de Química-Universidade Federal de São Carlos-CP 676, São Carlos-SP 13565-905, Brazil
7
Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P.O. Box 47, 237 Yaoundé, Cameroon
*
Authors to whom correspondence should be addressed.
Received: 27 April 2018 / Revised: 7 June 2018 / Accepted: 8 June 2018 / Published: 12 June 2018
(This article belongs to the Special Issue Fungal Endophytes in Plants)
View Full-Text   |   Download PDF [449 KB, uploaded 12 June 2018]   |  

Abstract

There is continuing need for new and improved drugs to tackle malaria, which remains a major public health problem, especially in tropical and subtropical regions of the world. Natural products represent credible sources of new antiplasmodial agents for antimalarial drug development. Endophytes that widely colonize healthy tissues of plants have been shown to synthesize a great variety of secondary metabolites that might possess antiplasmodial benefits. The present study was carried out to evaluate the antiplasmodial potential of extracts from endophytic fungi isolated from Symphonia globulifera against a chloroquine-resistant strain of Plasmodium falciparum (PfINDO). Sixty-one fungal isolates with infection frequency of 67.77% were obtained from the bark of S. globulifera. Twelve selected isolates were classified into six different genera including Fusarium, Paecilomyces, Penicillium, Aspergillus, Mucor, and Bipolaris. Extracts from the 12 isolates were tested against PfINDO, and nine showed good activity (IC50 < 10 μg·mL−1) with three fungi including Paecilomyces lilacinus (IC50 = 0.44 μg·mL−1), Penicillium janthinellum (IC50 = 0.2 μg·mL−1), and Paecilomyces sp. (IC50 = 0.55 μg·mL−1) showing the highest promise. These three isolates were found to be less cytotoxic against the HEK293T cell line with selectivity indices ranging from 24.52 to 70.56. Results from this study indicate that endophytic fungi from Symphonia globulifera are promising sources of hit compounds that might be further investigated as novel drugs against malaria. The chemical investigation of active extracts is ongoing. View Full-Text
Keywords: malaria; chloroquine-resistant Plasmodium falciparum; Symphonia globulifera; endophytic fungi; antiplasmodial IC50; selectivity index malaria; chloroquine-resistant Plasmodium falciparum; Symphonia globulifera; endophytic fungi; antiplasmodial IC50; selectivity index
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ateba, J.E.T.; Toghueo, R.M.K.; Awantu, A.F.; Mba’ning, B.M.; Gohlke, S.; Sahal, D.; Rodrigues-Filho, E.; Tsamo, E.; Boyom, F.F.; Sewald, N.; Lenta, B.N. Antiplasmodial Properties and Cytotoxicity of Endophytic Fungi from Symphonia globulifera (Clusiaceae). J. Fungi 2018, 4, 70.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top