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J. Fungi 2017, 3(4), 64; doi:10.3390/jof3040064

Adaptive Immunity to Cryptococcus neoformans Infections

Department of Microbiology and Immunology, Medical School, University of Minnesota, 689 23rd Ave SE, Minneapolis, MN 55455, USA
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Received: 17 October 2017 / Revised: 13 November 2017 / Accepted: 15 November 2017 / Published: 21 November 2017
(This article belongs to the Special Issue Mucosal Fungal Infections)
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Abstract

The Cryptococcus neoformans/Cryptococcus gattii species complex is a group of fungal pathogens with different phenotypic and genotypic diversity that cause disease in immunocompromised patients as well as in healthy individuals. The immune response resulting from the interaction between Cryptococcus and the host immune system is a key determinant of the disease outcome. The species C. neoformans causes the majority of human infections, and therefore almost all immunological studies focused on C. neoformans infections. Thus, this review presents current understanding on the role of adaptive immunity during C. neoformans infections both in humans and in animal models of disease. View Full-Text
Keywords: Cryptococcus; adaptive immunity; dendritic cells; CD4; helper T cell type 1 (Th1); helper T cell type 2 (Th2); helper T cell type 17 (Th17); cytokines; immune reconstitution inflammatory syndrome (IRIS) Cryptococcus; adaptive immunity; dendritic cells; CD4; helper T cell type 1 (Th1); helper T cell type 2 (Th2); helper T cell type 17 (Th17); cytokines; immune reconstitution inflammatory syndrome (IRIS)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mukaremera, L.; Nielsen, K. Adaptive Immunity to Cryptococcus neoformans Infections. J. Fungi 2017, 3, 64.

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