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J. Fungi 2017, 3(4), 63; https://doi.org/10.3390/jof3040063

Function and Biosynthesis of Cell Wall α-1,3-Glucan in Fungi

1,†
,
2,†
and
1,2,3,*
1
ABE-Project, New Industry Creation Hatchery Center, Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan
2
Laboratory of Applied Microbiology, Department of Microbial Biotechnology, Graduate School of Agricultural Sciences, Tohoku University, 468-1 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-0845, Japan
3
Department of Microbial Resources, Graduate School of Agricultural Science, Tohoku University, 468-1 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-0845, Japan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 10 October 2017 / Revised: 10 November 2017 / Accepted: 16 November 2017 / Published: 18 November 2017
(This article belongs to the Special Issue Fungal Cell Wall)
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Abstract

Although α-1,3-glucan is a major cell wall polysaccharide in filamentous fungi, its biological functions remain unclear, except that it acts as a virulence factor in animal and plant pathogenic fungi: it conceals cell wall β-glucan on the fungal cell surface to circumvent recognition by hosts. However, cell wall α-1,3-glucan is also present in many of non-pathogenic fungi. Recently, the universal function of α-1,3-glucan as an aggregation factor has been demonstrated. Applications of fungi with modified cell wall α-1,3-glucan in the fermentation industry and of in vitro enzymatically-synthesized α-1,3-glucan in bio-plastics have been developed. This review focuses on the recent progress in our understanding of the biological functions and biosynthetic mechanism of cell wall α-1,3-glucan in fungi. We briefly consider the history of studies on α-1,3-glucan, overview its biological functions and biosynthesis, and finally consider the industrial applications of fungi deficient in α-1,3-glucan. View Full-Text
Keywords: α-1,3-glucan; cell wall; filamentous fungi; dimorphic yeast; virulence factor; aggregation factor; Aspergillus α-1,3-glucan; cell wall; filamentous fungi; dimorphic yeast; virulence factor; aggregation factor; Aspergillus
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Yoshimi, A.; Miyazawa, K.; Abe, K. Function and Biosynthesis of Cell Wall α-1,3-Glucan in Fungi. J. Fungi 2017, 3, 63.

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