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J. Fungi 2017, 3(1), 14; doi:10.3390/jof3010014

The Candida albicans Biofilm Matrix: Composition, Structure and Function

1
Department of Biology, University of the Incarnate Word, San Antonio, TX 78209, USA
2
Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78294, USA
3
Department of Biomedical, Chemical & Materials Engineering, San José State University, San José, CA 95192, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Mahmoud A. Ghannoum
Received: 24 January 2017 / Revised: 28 February 2017 / Accepted: 3 March 2017 / Published: 8 March 2017
(This article belongs to the Special Issue Fungal Biofilms)
View Full-Text   |   Download PDF [901 KB, uploaded 8 March 2017]   |  

Abstract

A majority of infections caused by Candida albicans—the most frequent fungal pathogen—are associated with biofilm formation. A salient feature of C. albicans biofilms is the presence of the biofilm matrix. This matrix is composed of exopolymeric materials secreted by sessile cells within the biofilm, in which all classes of macromolecules are represented, and provides protection against environmental challenges. In this review, we summarize the knowledge accumulated during the last two decades on the composition, structure, and function of the C. albicans biofilm matrix. Knowledge of the matrix components, its structure, and function will help pave the way to novel strategies to combat C. albicans biofilm infections. View Full-Text
Keywords: Candida albicans; candidiasis; biofilms; extracellular matrix; antifungal resistance Candida albicans; candidiasis; biofilms; extracellular matrix; antifungal resistance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pierce, C.G.; Vila, T.; Romo, J.A.; Montelongo-Jauregui, D.; Wall, G.; Ramasubramanian, A.; Lopez-Ribot, J.L. The Candida albicans Biofilm Matrix: Composition, Structure and Function. J. Fungi 2017, 3, 14.

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