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J. Fungi 2016, 2(3), 23; doi:10.3390/jof2030023

PCR Technology for Detection of Invasive Aspergillosis

1
Department of Medical Microbiology and Infectious Diseases, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
2
Public Health Wales Microbiology, Cardiff CF14 4 XW, UK
*
Author to whom correspondence should be addressed.
Academic Editor: William J. Steinbach
Received: 1 April 2016 / Revised: 20 July 2016 / Accepted: 26 July 2016 / Published: 11 August 2016
(This article belongs to the Special Issue Aspergillus fumigatus: From Diagnosis to Therapy)
View Full-Text   |   Download PDF [202 KB, uploaded 11 August 2016]

Abstract

The application of molecular technologies to aid diagnosis and management of infectious diseases has had a major impact and many assays are in routine use. Diagnosis of aspergillosis has lagged behind. Lack of standardization and limited commercial interest have meant that PCR was not included in consensus diagnostic criteria for invasive fungal disease. In the last ten years careful evaluation and validation by the Aspergillus European PCR initiative with the development of standardized extraction, amplification and detection protocols for various specimen types, has provided the opportunity for clinical utility to be investigated. PCR has the potential to not only exclude a diagnosis of invasive aspergillosis but in combination with antigen testing may offer an approach for the early diagnosis and treatment of invasive aspergillosis in high-risk populations, with the added benefit of detection of genetic markers associated with antifungal resistance. View Full-Text
Keywords: Aspergillus infection; Aspergillus PCR Aspergillus infection; Aspergillus PCR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Barnes, R.A.; White, P.L. PCR Technology for Detection of Invasive Aspergillosis. J. Fungi 2016, 2, 23.

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