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J. Fungi 2015, 1(3), 293-331; doi:10.3390/jof1030293

Pneumocystis Pneumonia in Solid-Organ Transplant Recipients

1,2,3,4,* , 1,2,3,4
,
2,4,5,†
and
1,2,3,4,†,*
1
Department of Parasitology-Mycology, Centre Hospitalier Universitaire de Toulouse, Hôpital Purpan, Institut Fédératif de biologie (IFB), 330 avenue de Grande Bretagne, TSA 40031, Toulouse 31059, France
2
INSERM U1043, Toulouse F-31300, France
3
CNRS UMR5282, Toulouse F-31300, France
4
Université de Toulouse, UPS, Centre de Physiopathiologie de Toulouse Purpan (CPTP), Toulouse F-31300, France
5
Department of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, Toulouse 31059, France
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Shmuel Shoham
Received: 17 June 2015 / Revised: 1 September 2015 / Accepted: 2 September 2015 / Published: 28 September 2015
(This article belongs to the Special Issue Fungal Infections in Transplant Recipients)
View Full-Text   |   Download PDF [266 KB, uploaded 28 September 2015]   |  

Abstract

Pneumocystis pneumonia (PCP) is well known and described in AIDS patients. Due to the increasing use of cytotoxic and immunosuppressive therapies, the incidence of this infection has dramatically increased in the last years in patients with other predisposing immunodeficiencies and remains an important cause of morbidity and mortality in solid-organ transplant (SOT) recipients. PCP in HIV-negative patients, such as SOT patients, harbors some specificity compared to AIDS patients, which could change the medical management of these patients. This article summarizes the current knowledge on the epidemiology, risk factors, clinical manifestations, diagnoses, prevention, and treatment of Pneumocystis pneumonia in solid-organ transplant recipients, with a particular focus on the changes caused by the use of post-transplantation prophylaxis. View Full-Text
Keywords: Pneumocystis jirovecii; Pneumocystis pneumonia; transplantation; solid-organ transplant recipients Pneumocystis jirovecii; Pneumocystis pneumonia; transplantation; solid-organ transplant recipients
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Iriart, X.; Bouar, M.L.; Kamar, N.; Berry, A. Pneumocystis Pneumonia in Solid-Organ Transplant Recipients. J. Fungi 2015, 1, 293-331.

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