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J. Fungi 2015, 1(2), 252-276; doi:10.3390/jof1020252

Diagnostic Modalities for Invasive Mould Infections among Hematopoietic Stem Cell Transplant and Solid Organ Recipients: Performance Characteristics and Practical Roles in the Clinic

1
Department of Medicine, University of Pittsburgh Medical Center, Scaife Hall, Suite 871, 3550 Terrace Street, Pittsburgh, PA 15261, USA
2
Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, 200 Lothrop St. 301, Pittsburgh, PA 15213, USA
3
Department of Medicine, University of Pittsburgh, Scaife Hall, Suite 871, 3550 Terrace Street, Pittsburgh, PA 15261, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Shmuel Shoham
Received: 6 June 2015 / Revised: 28 August 2015 / Accepted: 31 August 2015 / Published: 10 September 2015
(This article belongs to the Special Issue Fungal Infections in Transplant Recipients)
View Full-Text   |   Download PDF [740 KB, uploaded 10 September 2015]

Abstract

The morbidity and mortality of hematopoietic stem cell and solid organ transplant patients with invasive fungal infections (IFIs) remain high despite an increase in the number of effective antifungal agents. Early diagnosis leading to timely administration of antifungal therapy has been linked to better outcomes. Unfortunately, the diagnosis of IFIs remains challenging. The current gold standard for diagnosis is a combination of histopathology and culture, for which the sensitivity is <50%. Over the past two decades, a plethora of non-culture-based antigen and molecular assays have been developed and clinically validated. In this article, we will review the performance of the current commercially available non-cultural diagnostics and discuss their practical roles in the clinic. View Full-Text
Keywords: invasive mould infections; aspergillosis; solid organ transplant; hematological malignancy; hematopoietic stem cell transplant; diagnostic biomarker; galactomannan; β-d-glucan; PCR invasive mould infections; aspergillosis; solid organ transplant; hematological malignancy; hematopoietic stem cell transplant; diagnostic biomarker; galactomannan; β-d-glucan; PCR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Haidar, G.; Falcione, B.A.; Nguyen, M.H. Diagnostic Modalities for Invasive Mould Infections among Hematopoietic Stem Cell Transplant and Solid Organ Recipients: Performance Characteristics and Practical Roles in the Clinic. J. Fungi 2015, 1, 252-276.

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