Next Article in Journal
The Nasal Nitric Oxide Response to External Acoustic Energy: A Pilot Study of Sampling Dynamics
Next Article in Special Issue
Chronic Rhinosinusitis and Obstructive Sleep Apnea: CPAP Reservoir Bacterial Colonization Is Not Associated with Sinus Culture Positivity
Previous Article in Journal
Sinusitis, Why a New Journal Dedicated Just to Sinusitis You Ask?
Article Menu

Export Article

Open AccessArticle
Sinusitis 2016, 1(1), 3-12; doi:10.3390/sinusitis1010003

Effect of a Chitosan-Based Biodegradable Middle Meatal Dressing after Endoscopic Sinus Surgery: A Prospective Randomized Comparative Study

Department of Otolaryngology, St Elizabeth's Medical Center, 736 Cambridge Street, SMC-8 Brighton, MA 02135, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Claudina A. Pérez Novo
Received: 10 October 2015 / Accepted: 7 November 2015 / Published: 25 November 2015
(This article belongs to the Special Issue Chronic Rhinosinusitis: Clinical and Immunological Research)
View Full-Text   |   Download PDF [683 KB, uploaded 18 December 2015]   |  

Abstract

Introduction: The use of biomaterials to improve wound healing after endoscopic sinus surgery (ESS) is not new. Many types of resorbable and non-resorbable materials have been tried as a middle meatal (MM) dressing, spacer, or stent to prevent lateralization of the middle turbinate, formation of synechia, granulation tissue, adhesions and scarring. The FDA has recently approved Chitosan-based nasal dressing/spacers which have optimal wound healing characteristics, including hemostatic and bacteriostatic properties. Herein, we compare a new chitosan-based biomaterial to a popular fully synthetic resorbable dressing in patients undergoing ESS. Materials and Methods: A prospective randomized controlled study was performed comparing a new Chitosan-based bioresorbable nasal dressing (Posi-Sep X) against a previously studied and well known fully synthetic polyurethane-based control (Nasopore). Post-operative outcome metrics included the degree of crusting, amount of retained implant, patient comfort, wound healing, epistaxis, and post-operative infection at two weeks. Results: Thirty-five patients were enrolled and a total seventy implants were placed (n = 70) at the completion of ESS. The results show a statistically significant difference between the Chitosan-based product and the control with respect to wound healing, degree of crusting, and resorption profile. In addition, the Chitosan-based dressing had a markedly lower requirement for post-operative debridement, and a lower incidence of epistaxis and infection, which corresponds to superior patient comfort. Conclusion: Our study is consistent with the biomaterials literature regarding the potential advantages of Chitosan-based MM dressings after ESS regarding improved wound healing, biocompatibility, and patient comfort. View Full-Text
Keywords: chitosan; biodegradable; middle meatal dressing; middle meatal spacer; endoscopic sinus surgery; NasoPore™; Posi-Sep X™; sinus stent chitosan; biodegradable; middle meatal dressing; middle meatal spacer; endoscopic sinus surgery; NasoPore™; Posi-Sep X™; sinus stent
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hsu, K.; Ericksen, M.; Catalano, P. Effect of a Chitosan-Based Biodegradable Middle Meatal Dressing after Endoscopic Sinus Surgery: A Prospective Randomized Comparative Study. Sinusitis 2016, 1, 3-12.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sinusitis EISSN 2309-107X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top