Functions of PDE3 Isoforms in Cardiac Muscle
AbstractIsoforms in the PDE3 family of cyclic nucleotide phosphodiesterases have important roles in cyclic nucleotide-mediated signalling in cardiac myocytes. These enzymes are targeted by inhibitors used to increase contractility in patients with heart failure, with a combination of beneficial and adverse effects on clinical outcomes. This review covers relevant aspects of the molecular biology of the isoforms that have been identified in cardiac myocytes; the roles of these enzymes in modulating cAMP-mediated signalling and the processes mediated thereby; and the potential for targeting these enzymes to improve the profile of clinical responses. View Full-Text
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Movsesian, M.; Ahmad, F.; Hirsch, E. Functions of PDE3 Isoforms in Cardiac Muscle. J. Cardiovasc. Dev. Dis. 2018, 5, 10.
Movsesian M, Ahmad F, Hirsch E. Functions of PDE3 Isoforms in Cardiac Muscle. Journal of Cardiovascular Development and Disease. 2018; 5(1):10.Chicago/Turabian Style
Movsesian, Matthew; Ahmad, Faiyaz; Hirsch, Emilio. 2018. "Functions of PDE3 Isoforms in Cardiac Muscle." J. Cardiovasc. Dev. Dis. 5, no. 1: 10.
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