Next Article in Journal
The Physiopathology of Cardiorenal Syndrome: A Review of the Potential Contributions of Inflammation
Previous Article in Journal
Kinking and Torsion Can Significantly Improve the Efficiency of Valveless Pumping in Periodically Compressed Tubular Conduits. Implications for Understanding of the Form-Function Relationship of Embryonic Heart Tubes
Previous Article in Special Issue
Current Perspectives in Cardiac Laterality
Article Menu

Export Article

Open AccessFeature PaperReview
J. Cardiovasc. Dev. Dis. 2017, 4(4), 20; doi:10.3390/jcdd4040020

Growth and Morphogenesis during Early Heart Development in Amniotes

Developmental Biology Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
Current Address: The Francis Crick Institute, London NW1 1AT, UK.
*
Authors to whom correspondence should be addressed.
Received: 15 October 2017 / Revised: 17 November 2017 / Accepted: 17 November 2017 / Published: 22 November 2017
View Full-Text   |   Download PDF [1823 KB, uploaded 22 November 2017]   |  

Abstract

In this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have provided abundant novel insights into heart development essential to understand the basis of congenital heart disease. Heart morphogenesis, however, is inherently a complex and dynamic three-dimensional process and we are far from understanding its cellular basis. Here, we discuss recent advances in studying heart morphogenesis and regionalization under the light of the pioneering work of Moorman and colleagues, which allowed the reinterpretation of regional gene expression patterns under a new morphogenetic framework. Two aspects of early heart formation will be discussed in particular: (1) the initial formation of the heart tube and (2) the formation of the cardiac chambers by the ballooning process. Finally, we emphasize that in addition to analyses based on fixed samples, new approaches including clonal analysis, single-cell sequencing, live-imaging and quantitative analysis of the data generated will likely lead to novel insights in understanding early heart tube regionalization and morphogenesis in the near future. View Full-Text
Keywords: heart tube; cardiac crescent; cardiac differentiation; first heart field; second heart field; cardiomyocyte; live-imaging heart tube; cardiac crescent; cardiac differentiation; first heart field; second heart field; cardiomyocyte; live-imaging
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ivanovitch, K.; Esteban, I.; Torres, M. Growth and Morphogenesis during Early Heart Development in Amniotes. J. Cardiovasc. Dev. Dis. 2017, 4, 20.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top