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Geriatrics 2018, 3(2), 23; https://doi.org/10.3390/geriatrics3020023

Using the A/T/N Framework to Examine Driving in Preclinical Alzheimer’s Disease

1
Knight Alzheimer Disease Research Center, Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
2
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
3
VITAS Healthcare, St. Louis, MO 63110, USA
4
Knight Alzheimer Disease Research Center, Departments of Radiology and Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA
5
Knight Alzheimer Disease Research Center, Department of Neurology, the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA
6
Knight Alzheimer Disease Research Center, Departments of Neurology, Neurosurgery, Occupational Therapy, Pathology and Immunology, Physical Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA
*
Author to whom correspondence should be addressed.
Received: 11 March 2018 / Revised: 20 April 2018 / Accepted: 25 April 2018 / Published: 2 May 2018
(This article belongs to the Special Issue Aging and Driving)
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Abstract

The A/T/N classification system is the foundation of the 2018 NIA-AA Research Framework and is intended to guide the Alzheimer disease (AD) research agenda for the next 5–10 years. Driving is a widespread functional activity that may be particularly useful in investigation of functional changes in pathological AD before onset of cognitive symptoms. We examined driving in preclinical AD using the A/T/N framework and found that the onset of driving difficulties is most associated with abnormality of both amyloid and tau pathology, rather than amyloid alone. These results have implications for participant selection into clinical trials and for the application time of interventions aimed at prolonging the time of safe driving among older adults with preclinical AD. View Full-Text
Keywords: Alzheimer disease; preclinical Alzheimer disease; dementia; driving; biomarkers; cerebrospinal fluid; imaging Alzheimer disease; preclinical Alzheimer disease; dementia; driving; biomarkers; cerebrospinal fluid; imaging
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Roe, C.M.; Babulal, G.M.; Stout, S.H.; Carr, D.B.; Williams, M.M.; Benzinger, T.L.S.; Fagan, A.M.; Holtzman, D.M.; Ances, B.M.; Morris, J.C. Using the A/T/N Framework to Examine Driving in Preclinical Alzheimer’s Disease. Geriatrics 2018, 3, 23.

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