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Bioengineering 2018, 5(3), 60; https://doi.org/10.3390/bioengineering5030060

Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps

Chair of Organic Chemistry I, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany
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Received: 11 July 2018 / Revised: 27 July 2018 / Accepted: 30 July 2018 / Published: 1 August 2018
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Abstract

A proof of concept for a one-pot process merging a heterocycle formation by a classical chemical approach at basic conditions with a biocatalytic reduction, running at neutral pH conditions, is reported. A crucial component for this process is the compartmentalization of the single reactions by the use of polydimethylsiloxane thimbles. This process was applied successfully towards an asymmetric synthesis of (S)-2,2,3-trimethyl-1-thia-4-azaspiro[4.4]nonane, leading to excellent enantioselectivities of 99% enantiomeric excess (ee). View Full-Text
Keywords: Asinger-type multi-component reaction; asymmetric synthesis; biocatalysis; cascades; compartmentalization; heterocycles Asinger-type multi-component reaction; asymmetric synthesis; biocatalysis; cascades; compartmentalization; heterocycles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Zumbrägel, N.; Gröger, H. Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps. Bioengineering 2018, 5, 60.

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