Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review
AbstractPhotobiomodulation therapy (PBMT) has been investigated because of its intimate relationship with tissue recovery processes, such as on peripheral nerve damage. Based on the wide range of benefits that the PBMT has shown and its clinical relevance, the aim of this research was to carry out a systematic review of the last 10 years, ascertaining the influence of the PBMT in the regeneration of injured peripheral nerves. The search was performed in the PubMed/MEDLINE database with the combination of the keywords: low-level laser therapy AND nerve regeneration. Initially, 54 articles were obtained, 26 articles of which were chosen for the study according to the inclusion criteria. In the qualitative aspect, it was observed that PBMT was able to accelerate the process of nerve regeneration, presenting an increase in the number of myelinated fibers and a better lamellar organization of myelin sheath, besides improvement of electrophysiological function, immunoreactivity, high functionality rate, decrease of inflammation, pain, and the facilitation of neural regeneration, release of growth factors, increase of vascular network and collagen. It was concluded that PBMT has beneficial effects on the recovery of nerve lesions, especially when related to a faster regeneration and functional improvement, despite the variety of parameters. View Full-Text
Share & Cite This Article
Rosso, M.P.O.; Buchaim, D.V.; Kawano, N.; Furlanette, G.; Pomini, K.T.; Buchaim, R.L. Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review. Bioengineering 2018, 5, 44.
Rosso MPO, Buchaim DV, Kawano N, Furlanette G, Pomini KT, Buchaim RL. Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review. Bioengineering. 2018; 5(2):44.Chicago/Turabian Style
Rosso, Marcelie P.O.; Buchaim, Daniela V.; Kawano, Natália; Furlanette, Gabriela; Pomini, Karina T.; Buchaim, Rogério L. 2018. "Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review." Bioengineering 5, no. 2: 44.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.