Bioengineering 2018, 5(1), 23; https://doi.org/10.3390/bioengineering5010023
Stem Cells and Engineered Scaffolds for Regenerative Wound Healing
Biraja C. Dash 1,*
, Zhenzhen Xu 1, Lawrence Lin 2, Andrew Koo 1, Sifon Ndon 1, Francois Berthiaume 3, Alan Dardik 4 and Henry Hsia 1,*
, Zhenzhen Xu 1, Lawrence Lin 2, Andrew Koo 1, Sifon Ndon 1, Francois Berthiaume 3, Alan Dardik 4 and Henry Hsia 1,*
1
Department of Surgery (Plastic), Yale School of Medicine, New Haven, CT 06510, USA
2
Department of Public Health Studies, Johns Hopkins University, Baltimore, MD 21218, USA
3
Department of Biomedical Engineering, Rutgers University, The State University New Jersey, Piscataway, NJ 08901, USA
4
Department of Surgery (Vascular), Yale School of Medicine, New Haven, CT 06510, USA
*
Authors to whom correspondence should be addressed.
Received: 15 February 2018 / Revised: 5 March 2018 / Accepted: 8 March 2018 / Published: 9 March 2018
(This article belongs to the Special Issue Advances in Wound Healing Systems)
Abstract
The normal wound healing process involves a well-organized cascade of biological pathways and any failure in this process leads to wounds becoming chronic. Non-healing wounds are a burden on healthcare systems and set to increase with aging population and growing incidences of obesity and diabetes. Stem cell-based therapies have the potential to heal chronic wounds but have so far seen little success in the clinic. Current research has been focused on using polymeric biomaterial systems that can act as a niche for these stem cells to improve their survival and paracrine activity that would eventually promote wound healing. Furthermore, different modification strategies have been developed to improve stem cell survival and differentiation, ultimately promoting regenerative wound healing. This review focuses on advanced polymeric scaffolds that have been used to deliver stem cells and have been tested for their efficiency in preclinical animal models of wounds. View Full-TextKeywords:
chronic wound; scaffold; natural polymer; synthetic polymer; stem cell; surface modification
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Dash, B.C.; Xu, Z.; Lin, L.; Koo, A.; Ndon, S.; Berthiaume, F.; Dardik, A.; Hsia, H. Stem Cells and Engineered Scaffolds for Regenerative Wound Healing. Bioengineering 2018, 5, 23.
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