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Bioengineering 2018, 5(1), 16; https://doi.org/10.3390/bioengineering5010016

Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement

1
Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA
2
Department of Pharmacology, Government Medical College, Bhavnagar 364002, Gujarat, India
3
Analytical Discipline and Centralized Instrument Facility, The Academy of Scientific & Innovative Research (AcSIR), Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar 364002, Gujarat, India
Present address: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
*
Author to whom correspondence should be addressed.
Received: 29 December 2017 / Revised: 4 February 2018 / Accepted: 7 February 2018 / Published: 13 February 2018
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Abstract

The aim of the present study was to make a fenofibrate (FNB) nanocrystal (NC) by wet media milling, characterizations and formulates into oral strip-films (OSFs). Mechanical properties, redispersion study, and solid-state characterizations results suggested that reduction of drug crystal size at nanoscale and incorporation into OSFs does not affect the solid-state properties of the drug. In vitro dissolution kinetics showed enhanced dissolution rate was easily manipulated by changing the thickness of the OSF. In situ UV-imaging was used to monitor drug dissolution qualitatively and quantitatively in real time. Results confirm that the intrinsic dissolution rates and surface drug concentration measured with this device were in agreement with the USP-IV dissolution profiles. In vivo pharmacokinetics in rabbits showed a significant difference in the pharmacokinetics parameter (1.4 fold increase bioavailability) of FNB NC-loaded OSFs as compared to the marketed formulation “Tricor” and as-received (pristine) drug. This approach of drug nanocrystallization and incorporation into OSFs may have significant applications in cost-effective tools for bioavailability enhancement of FNB. View Full-Text
Keywords: bioavailability; fenofibrate; media milling; pharmacokinetics; UV imaging bioavailability; fenofibrate; media milling; pharmacokinetics; UV imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kevadiya, B.D.; Barvaliya, M.; Zhang, L.; Anovadiya, A.; Brahmbhatt, H.; Paul, P.; Tripathi, C. Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement. Bioengineering 2018, 5, 16.

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