Next Article in Journal
Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials
Next Article in Special Issue
Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review
Previous Article in Journal
Acknowledgement to Reviewers of Bioengineering in 2016
Previous Article in Special Issue
Biosilica from Living Diatoms: Investigations on Biocompatibility of Bare and Chemically Modified Thalassiosira weissflogii Silica Shells
Article Menu

Export Article

Open AccessReview
Bioengineering 2017, 4(1), 3; doi:10.3390/bioengineering4010003

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

1
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, E-28040 Madrid, Spain
2
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid 28029, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Chiara Vitale-Brovarone
Received: 20 December 2016 / Revised: 12 January 2017 / Accepted: 16 January 2017 / Published: 18 January 2017
View Full-Text   |   Download PDF [5593 KB, uploaded 18 January 2017]   |  

Abstract

The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents. View Full-Text
Keywords: mesoporous nanoparticles; pH-responsive; cancer; stimuli-responsive mesoporous nanoparticles; pH-responsive; cancer; stimuli-responsive
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gisbert-Garzarán, M.; Manzano, M.; Vallet-Regí, M. pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery. Bioengineering 2017, 4, 3.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Bioengineering EISSN 2306-5354 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top