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Bioengineering 2016, 3(1), 10; doi:10.3390/bioengineering3010010

Metabolic Engineering Strategies for Co-Utilization of Carbon Sources in Microbes

1
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China
2
BioChemical Engineering Program, College of Engineering, University of Georgia, Athens, GA 30602, USA
*
Authors to whom correspondence should be addressed.
Received: 20 November 2015 / Accepted: 25 January 2016 / Published: 6 February 2016
(This article belongs to the Special Issue Metabolic Engineering)
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Abstract

Co-utilization of carbon sources in microbes is an important topic in metabolic engineering research. It is not only a way to reduce microbial production costs but also an attempt for either improving the yields of target products or decreasing the formation of byproducts. However, there are barriers in co-utilization of carbon sources in microbes, such as carbon catabolite repression. To overcome the barriers, different metabolic engineering strategies have been developed, such as inactivation of the phosphotransferase system and rewiring carbon assimilation pathways. This review summarizes the most recent developments of different strategies that support microbes to utilize two or more carbon sources simultaneously. The main content focuses on the co-utilization of glucose and pentoses, major sugars in lignocellulose. View Full-Text
Keywords: metabolic engineering strategies; co-utilization; lignocellulosic biomass metabolic engineering strategies; co-utilization; lignocellulosic biomass
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wu, Y.; Shen, X.; Yuan, Q.; Yan, Y. Metabolic Engineering Strategies for Co-Utilization of Carbon Sources in Microbes. Bioengineering 2016, 3, 10.

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