Next Article in Journal
Rebalancing Redox to Improve Biobutanol Production by Clostridium tyrobutyricum
Previous Article in Journal
Applying Acylated Fucose Analogues to Metabolic Glycoengineering
Article Menu

Export Article

Open AccessArticle
Bioengineering 2016, 3(1), 1; doi:10.3390/bioengineering3010001

Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes

1
Center for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA 71272, USA
2
Wayne State University, St. John Hospital & Medical Center, 22101 Moross Rd, Detroit, MI 48236, USA
3
School of Biological Sciences, Louisiana Tech University, Ruston, LA 1272, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ali Khademhosseini
Received: 30 August 2015 / Revised: 16 November 2015 / Accepted: 16 December 2015 / Published: 23 December 2015
View Full-Text   |   Download PDF [6924 KB, uploaded 23 December 2015]   |  

Abstract

The use of nanomaterials for improving drug delivery methods has been shown to be advantageous technically and viable economically. This study employed the use of halloysite nanotubes (HNTs) as nanocontainers, as well as enhancers of structural integrity in electrospun poly-e-caprolactone (PCL) scaffolds. HNTs were loaded with amoxicillin, Brilliant Green, chlorhexidine, doxycycline, gentamicin sulfate, iodine, and potassium calvulanate and release profiles assessed. Selected doped halloysite nanotubes (containing either Brilliant Green, amoxicillin and potassium calvulanate) were then mixed with poly-e-caprolactone (PLC) using the electrospinning method and woven into random and oriented-fibered nanocomposite mats. The rate of drug release from HNTs, HNTs/PCL nanocomposites, and their effect on inhibiting bacterial growth was investigated. Release profiles from nanocomposite mats showed a pattern of sustained release for all bacterial agents. Nanocomposites were able to inhibit bacterial growth for up to one-month with only a slight decrease in bacterial growth inhibition. We propose that halloysite doped nanotubes have the potential for use in a variety of medical applications including sutures and surgical dressings, without compromising material properties. View Full-Text
Keywords: antiseptics; antibiotics; drug release; halloysite nanotubes; nanocontainers; poly-e-caprolactone; nanocomposite mats antiseptics; antibiotics; drug release; halloysite nanotubes; nanocontainers; poly-e-caprolactone; nanocomposite mats
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Patel, S.; Jammalamadaka, U.; Sun, L.; Tappa, K.; Mills, D.K. Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes. Bioengineering 2016, 3, 1.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Bioengineering EISSN 2306-5354 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top