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Medicines 2018, 5(2), 49; https://doi.org/10.3390/medicines5020049

Efficacy of Four Solanum spp. Extracts in an Animal Model of Cutaneous Leishmaniasis

1
Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, 2000 Antwerpen, Belgium
2
Parasitology Department, Institute of Tropical Medicine “Pedro Kouri”, Havana 10400, Cuba
3
Academic Unit of Chemical Sciences and Health, Technical University of Machala, Machala 070101, Ecuador
4
Research Department, Laboratories of Biopharmaceuticals and Chemistries Productions (LABIOFAM), Havana 10400, Cuba
5
UNESP—São Paulo State University, Coastal Campus of São Vicente, São Paulo 19014-020, SP, Brazil
*
Author to whom correspondence should be addressed.
Received: 27 April 2018 / Revised: 15 May 2018 / Accepted: 25 May 2018 / Published: 5 June 2018
(This article belongs to the Special Issue Bioactivities and Medical Use of Herbs and Plants)
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Abstract

Background: Leishmaniasis is a complex protozoa disease caused by Leishmania genus (Trypanosomatidae family). Currently, there have been renewed interests worldwide in plants as pharmaceutical agents. In this study, the in vivo efficacy of Solanum spp. is assessed in an L. amazonensis BALB/c mice model for experimental cutaneous leishmaniasis. Methods: Animals were infected with 5 × 106 metacyclic promastigotes and 30-day post-infection, a treatment with 30 mg/kg of Solanum extracts or Glucantime® (GTM) was applied intralesionally every four days to complete 5 doses. Results: Neither death nor loss of weight higher than 10% was observed. All the tested extracts were able to control the infection, compared with the infected and untreated group. Solanum havanense Jacq. extract showed the highest efficacy and was superior (p < 0.05) to GTM. Solanum myriacanthum Dunal., S. nudum Dunal. and S. seaforthianum Andr. extracts demonstrated a similar effect (p > 0.05) to GTM. An increase of IFN-γ (p < 0.05) was displayed only by animals treated with S. nudum compared to the group treated with a vehicle, while no differences (p > 0.05) were observed for IL-12. Conclusions: In vivo effects of Solanum extracts were demonstrated, suggesting that this genus could be further explored as a new antileishmanial alternative. View Full-Text
Keywords: Leishmania amazonensis; cutaneous leishmaniasis; BALB/c mice; Solanum havanense; Solanum myriacanthum; Solanum nudum; Solanum seaforthianum Leishmania amazonensis; cutaneous leishmaniasis; BALB/c mice; Solanum havanense; Solanum myriacanthum; Solanum nudum; Solanum seaforthianum
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Cos, P.; Janssens, J.; Piñón, A.; Cuesta-Rubio, O.; Yglesias-Rivera, A.; Díaz-García, A.; Vilegas, W.; Monzote, L. Efficacy of Four Solanum spp. Extracts in an Animal Model of Cutaneous Leishmaniasis. Medicines 2018, 5, 49.

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