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Medicines 2018, 5(1), 8; https://doi.org/10.3390/medicines5010008

Estrogen and Thyroid Hormone Receptor Activation by Medicinal Plants from Bahia, Brazil

1
Laboratory of Bioprospection and Biotechnology (LaBBiotec), Institute of Biology, Federal University of Bahia (UFBA), Barão de Jeremoabo Street, 147-Ondina, Salvador, BA 40170-115, Brazil
2
Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Federal University of São Paulo (UNIFESP), R. Sena Madureira, 1500-Vila Clementino, São Paulo, SP 04021-001, Brazil
3
Laboratory of Neurochemistry and Cell Biology, Department of Biofunction, Institute of Health Sciences, Federal University of Bahia (UFBA), Reitor Miguel Calmon Avenue, 1272-Canela, Salvador, BA 40231-300, Brazil
4
Laboratory of Research in Materia Medica, Department of Medicament, Faculty of Pharmacy, Federal University of Bahia (UFBA), Barão de Jeremoabo Street, 147-Ondina, Salvador, BA 40170-115, Brazil
5
Department of Organic Chemistry, Institute of Chemistry, Federal University of Bahia (UFBA), Barão de Jeremoabo Street, 147-Ondina, Salvador, BA 40170-115, Brazil
*
Author to whom correspondence should be addressed.
Received: 23 December 2017 / Revised: 9 January 2018 / Accepted: 11 January 2018 / Published: 15 January 2018
(This article belongs to the Special Issue Bioactivities and Medical Use of Herbs and Plants)
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Abstract

Background: A number of medicinal plants are traditionally used for metabolic disorders in Bahia state, Brazil. The aim of this study was to evaluate the estrogen receptor (ER) and thyroid receptor (TR) activation of crude extracts prepared from 20 plants. Methods: Species were extracted and assayed for receptor activation through both ER and TR gene-reporter assays, using 17β-estradiol and triiodothyronine (T3), respectively, as the positive controls. Results: Cajanus cajan (Fabaceae), Abarema cochliacarpus (Fabaceae), and Borreria verticillata (Rubiaceae) were able to activate ER as much as the positive control (17β-estradiol). These three plant species were also assayed for TR activation. At the concentration of 50 µg/mL, C. cajans exerted the highest positive modulation on TR, causing an activation of 59.9%, while B. verticillata and A. cochliacarpus caused 30.8% and 23.3%, respectively. Conclusions: Our results contribute towards the validation of the traditional use of C. cajans, B. verticillata, and A. cochliacarpus in the treatment of metabolic disorders related to ER and TR functions. The gene-reporter assay was proven effective in screening crude plant extracts for ER/TR activation, endorsing this methodology as an important tool for future bioprospection studies focused on identifying novel starting molecules for the development of estrogen and thyroid agonists. View Full-Text
Keywords: nuclear receptor; estrogen hormone receptor; thyroid hormone receptor; metabolic disorders; Brazilian medicinal plants nuclear receptor; estrogen hormone receptor; thyroid hormone receptor; metabolic disorders; Brazilian medicinal plants
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Reis, L.T.C.; da Silva, M.R.D.; Costa, S.L.; Velozo, E.S.; Batista, R.; da Cunha Lima, S.T. Estrogen and Thyroid Hormone Receptor Activation by Medicinal Plants from Bahia, Brazil. Medicines 2018, 5, 8.

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