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Medicines 2017, 4(3), 55; doi:10.3390/medicines4030055

Chemical Composition, Antifungal and Antioxidant Activities of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) Essential Oils

1
Programa de Pós-Graduação em Biodiversidade Vegetal e Meio Ambiente, Instituto de Botânica de São Paulo, São Paulo 04301-902, Brazil
2
Instituto de Botânica de São Paulo, São Paulo 04301-902, Brazil
3
Laboratório de Quimioinformática, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil
4
Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Eleni Skaltsa
Received: 30 June 2017 / Accepted: 13 July 2017 / Published: 17 July 2017
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Abstract

Background: Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) is a dioecious shrub popularly used in Brazil to treat foot fungi and rheumatism. This work investigated the chemical composition, antifungal, and antioxidant activities of flowers and leaves of H. brasiliense essential oils; Methods: H. brasiliense male and female flowers and leaves were collected at Ilha do Cardoso (São Paulo) and the essential oils were extracted by hydrodistillation and analyzed by GC/MS and their similarity compared by Principal Component Analysis. Antifungal activity was performed by bioautography and antioxidant potential by 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) free radical scavenging and β-carotene/linoleic acid system; Results: The major compounds for all oils were sabinene, curzerene, and carotol, but some differences in their chemical composition were discriminated by Principal Component Analysis (PCA) analysis. Bioautography showed two antifungal bands at Rf’s 0.67 and 0.12 in all samples, the first one was identified as curzerene. The oils presented stronger antioxidant potential in β-carotene/linoleic acid bioassay, with IC50’s from 80 to 180 μg/mL, than in DPPH assay, with IC50’s from 2516.18 to 3783.49 μg/mL; Conclusions: These results suggested that curzerene might be responsible for the antifungal activity of H. brasiliense essential oils. Besides, these essential oils exhibited potential to prevent lipoperoxidation, but they have a weak radical scavenger activity. View Full-Text
Keywords: Hedyosmum brasiliense; essential oil; GC-MS; bioautography; curzerene; antioxidant; Atlantic Rain Forest Hedyosmum brasiliense; essential oil; GC-MS; bioautography; curzerene; antioxidant; Atlantic Rain Forest
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MDPI and ACS Style

Murakami, C.; Cordeiro, I.; Scotti, M.T.; Moreno, P.R.H.; Young, M.C.M. Chemical Composition, Antifungal and Antioxidant Activities of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) Essential Oils. Medicines 2017, 4, 55.

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