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Foods 2015, 4(4), 678-689; doi:10.3390/foods4040678

Nitric Oxide and Lutein: Function, Performance, and Protection of Neural Tissue

Nutritional Neuroscience Laboratory, Department of Psychology, University of Georgia, Athens, GA 30602, USA
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Christopher J. Smith
Received: 16 September 2015 / Revised: 23 October 2015 / Accepted: 5 November 2015 / Published: 11 November 2015
(This article belongs to the Special Issue Dietary Carotenoids and The Nervous System)
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Abstract

The soluble gas neurotransmitter nitric oxide (NO) serves many important metabolic and neuroregulatory functions in the retina and brain. Although it is necessary for normal neural function, NO can play a significant role in neurotoxicity. This is often seen in disease states that involve oxidative stress and inflammation of neural tissues, such as age-related macular degeneration and Alzheimer’s disease. The dietary xanthophyll carotenoid lutein (L) is a potent antioxidant and anti-inflammatory agent that, if consumed in sufficient amounts, is deposited in neural tissues that require substantial metabolic demand. Some of these specific tissues, such as the central retina and frontal lobes of the brain, are impacted by age-related diseases such as those noted above. The conspicuous correspondence between metabolic demand, NO, and L is suggestive of a homeostatic relationship that serves to facilitate normal function, enhance performance, and protect vulnerable neural tissues. The purpose of this paper is to review the literature on these points. View Full-Text
Keywords: lutein; nitric oxide; oxidative stress; inflammation lutein; nitric oxide; oxidative stress; inflammation
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Stringham, J.M.; Stringham, N.T. Nitric Oxide and Lutein: Function, Performance, and Protection of Neural Tissue. Foods 2015, 4, 678-689.

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