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New Direct Oral Anticoagulants (DOAC) and Their Use Today
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Dent. J. 2016, 4(1), 7; doi:10.3390/dj4010007

Direct Oral Anticoagulants in Dental Patients Including the Frail Elderly Population

1,2,* and 1,2,†
1
Department of Haematology, Northern Health, 185 Cooper Street, Epping VIC 3076, Australia
2
Department of Haematology, Austin Health, Studley Road, Heidelberg VIC 3084, Australia
The authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Claude Jaquiéry
Received: 5 December 2015 / Revised: 11 February 2016 / Accepted: 14 March 2016 / Published: 19 March 2016
(This article belongs to the Special Issue Medically Compromised Patients in Dentistry)
View Full-Text   |   Download PDF [518 KB, uploaded 19 March 2016]   |  

Abstract

Direct oral anticoagulants (DOACs) have led to a paradigm shift in the field of anticoagulation, providing safe and convenient anticoagulation without the need for regular blood testing. Currently, there are three major DOACs available—Factor Xa inhibitors (apixaban and rivaroxaban) and direct thrombin inhibitors (dabigatran)—that are available for use in atrial fibrillation and venous thromboembolism. While these agents have been shown to be as effective as warfarin, with a similar or better bleeding profile, there remains some concern of the use of these drugs in vulnerable populations, such as the frail elderly patients; particularly since reversal agents and drug monitoring are not routinely available. We aim to provide a review of the use of DOACs and the impact of DOACs on dental treatment in the elderly population. View Full-Text
Keywords: direct oral anticoagulants; factor Xa inhibitor; direct thrombin inhibitor; bleeding; frail elderly direct oral anticoagulants; factor Xa inhibitor; direct thrombin inhibitor; bleeding; frail elderly
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lim, H.Y.; Ho, P. Direct Oral Anticoagulants in Dental Patients Including the Frail Elderly Population. Dent. J. 2016, 4, 7.

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