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Inorganics 2018, 6(3), 87; https://doi.org/10.3390/inorganics6030087

The Importance of Solvent Effects on the Mechanism of the Pfeiffer Effect

Department of Chemistry, San José State University, One Washington Square, San José, CA 95192-0101, USA
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Received: 15 June 2018 / Revised: 30 July 2018 / Accepted: 10 August 2018 / Published: 29 August 2018
(This article belongs to the Special Issue Chiral Metal Complexes)
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Abstract

The Pfeiffer effect is observed when an optically active compound such as an amino acid is introduced to a solution containing a labile racemic metal complex, and an equilibrium shift is obtained. The “perturbation” results in an excess of one enantiomer over the other. The shift is a result of a preferential outer sphere interaction between the introduced chiral species and one enantiomeric form (Λ or ∆) of a labile metal complex. Speculations regarding the mechanism of the Pfeiffer effect have attributed observations to a singular factor such as pH, solvent polarity, or numerous other intermolecular interactions. Through the use of the lanthanide(III) complexes [Tb(DPA)3]3− and [Eu(DPA)3]3− (where DPA = 2,6-pyridinedicarboxylate) and the amino acids l-serine and l-proline; it is becoming clear that the mechanism is not so simply described as per the preliminary findings that are discussed in this study. It appears that the true mechanism is far more complicated than the attribute just a singular factor. This work attempts to shine light on the fact that understanding the behavior of the solvent environment may hypothetically be the key to offering a more detailed description of the mechanism. View Full-Text
Keywords: circularly polarized luminescence; chirality transfer; hydrophobic interactions; D3 lanthanide(III) complexes; chiral amino acid; solvent packing circularly polarized luminescence; chirality transfer; hydrophobic interactions; D3 lanthanide(III) complexes; chiral amino acid; solvent packing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Lunkley, J.L.; Nguyen, N.M.; Tuminaro, K.M.; Margittai, D.; Muller, G. The Importance of Solvent Effects on the Mechanism of the Pfeiffer Effect. Inorganics 2018, 6, 87.

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