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Inorganics 2017, 5(3), 44; doi:10.3390/inorganics5030044

Synthesis and In Vitro (Anticancer) Evaluation of η6-Arene Ruthenium Complexes Bearing Stannyl Ligands

1
Maastricht Science Programme, Faculty of Humanities and Science, Maastricht University, Kapoenstraat 2, P.O. Box 616, 6200 MD Maastricht, The Netherlands
2
Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
3
Institut für Anorganische Chemie, Technische Universität Graz, Stremayrgasse 9, A-8010 Graz, Austria
4
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH­1015 Lausanne, Switzerland
5
Biosorption and Water Research Laboratory Department of Chemistry, Vaal University of Technology, Private Bag X021, Andries Potgieter Blvd, Vanderbijlpark 1911, South Africa
*
Author to whom correspondence should be addressed.
Academic Editor: Luigi Messori
Received: 13 June 2017 / Revised: 5 July 2017 / Accepted: 11 July 2017 / Published: 13 July 2017
(This article belongs to the Special Issue Tumor Inhibiting Metal Complexes)
View Full-Text   |   Download PDF [2095 KB, uploaded 13 July 2017]   |  

Abstract

Treatment of the known half-sandwich complexes of the type [(η6-C6H6)RuCl2(P(OR)3)] (R = Me or Ph) with SnCl2 yielded three new half-sandwich ruthenium complexes (C1C3): [(η6-C6H6)RuCl(SnCl3)(P(OMe)3)] (C1), [(η6-C6H6)RuCl(SnCl3)(P(OPh)3)] (C2) and the bis-stannyl complex [(η6-C6H6)Ru(SnCl3)2(P(OMe)3)] (C3) by facile insertion of SnCl2 into the Ru–Cl bonds. Treatment of the known complexes [(η6-C6H6)RuCl(SnCl3)(PPh3)] and [(η6-C6H6)RuCl2(PPh3)] with 4-dimethylaminopyridine (DAMP) and ammonium tetrafluoroborate afforded the complex salts: [(η6-C6H6)Ru(SnCl3)(PPh3)(DAMP)]+BF4 (C4) and [(η6-C6H6)RuCl(PPh3)(DAMP)]+BF4 (C5) respectively. Complexes C1C5 have been fully characterized by spectroscopic means (IR, UV–vis, multinuclear NMR, ESI–MS) and their thermal behaviour elucidated by thermal gravimetric analysis (TGA). Structural characterization by single crystal X-ray crystallography of the novel complex C2 and [(η6-C6H6)RuCl2(P(OPh)3)], the latter having escaped elucidation by this method, is also reported. Finally, the cytotoxicity of the complexes was determined on the A2780 (human ovarian cancer), A2780cisR (human ovarian cis-platin-resistant cancer), and the HEK293 (human embryonic kidney) cell lines and discussed, and an attempt is made to elucidate the effect of the stannyl ligand on cytotoxicity. View Full-Text
Keywords: bioorganometallic chemistry; metal-based drugs; phosphorus ligands; ruthenium; half-sandwich complexes; tin dichloride insertion bioorganometallic chemistry; metal-based drugs; phosphorus ligands; ruthenium; half-sandwich complexes; tin dichloride insertion
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MDPI and ACS Style

Renier, O.; Deacon-Price, C.; Peters, J.E.B.; Nurekeyeva, K.; Russon, C.; Dyson, S.; Ngubane, S.; Baumgartner, J.; Dyson, P.J.; Riedel, T.; Chiririwa, H.; Blom, B. Synthesis and In Vitro (Anticancer) Evaluation of η6-Arene Ruthenium Complexes Bearing Stannyl Ligands. Inorganics 2017, 5, 44.

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