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Open AccessCommunication
Photonics 2016, 3(3), 48; doi:10.3390/photonics3030048

Photodynamic Therapy-Induced Microvascular Changes in a Nonmelanoma Skin Cancer Model Assessed by Photoacoustic Microscopy and Diffuse Correlation Spectroscopy

1
Department of Biomedical, Industrial & Human Factors Engineering, Wright State University, Dayton, OH 45432, USA
2
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
3
Department of Biomedical Engineering, Baskent University, Baglıca, Ankara 06810, Turkey
4
Department of Biomedical Engineering, University at Buffalo, Buffalo, NY 14260, USA
*
Author to whom correspondence should be addressed.
Received: 18 July 2016 / Revised: 31 July 2016 / Accepted: 2 August 2016 / Published: 5 August 2016
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Abstract

One of the main mechanisms of action for photodynamic therapy (PDT) is the destruction of tumor vasculature. We observed the PDT-induced vasculature destruction in a mouse model of skin cancer using two techniques: Photoacoustic microscopy (PAM) and diffuse correlation spectroscopy (DCS). PAM showed high-resolution images of the abnormal microvasculature near the establishing tumor area at pre-PDT, as well as the subsequent destruction of those vessels post-PDT. DCS indicated a significant blood flow decrease after PDT, confirming the vascular destruction. Noninvasive assessment of vascular changes may be indicative of therapy response. View Full-Text
Keywords: skin cancer; microvasculature; photoacoustic microscopy; blood flow; photodynamic therapy skin cancer; microvasculature; photoacoustic microscopy; blood flow; photodynamic therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rohrbach, D.J.; Salem, H.; Aksahin, M.; Sunar, U. Photodynamic Therapy-Induced Microvascular Changes in a Nonmelanoma Skin Cancer Model Assessed by Photoacoustic Microscopy and Diffuse Correlation Spectroscopy. Photonics 2016, 3, 48.

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