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Separations 2016, 3(2), 12; doi:10.3390/separations3020012

Exploring Gradients in Electrophoretic Separation and Preconcentration on Miniaturized Devices

School of Molecular Sciences, Arizona State University, Tempe, AZ 85274, USA
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Author to whom correspondence should be addressed.
Academic Editor: Timothy Strein
Received: 14 December 2015 / Revised: 22 February 2016 / Accepted: 2 March 2016 / Published: 1 April 2016
(This article belongs to the Special Issue Electrophoretic Analyses in Capillaries and Microfluidic Devices)
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Abstract

Over the last two decades, miniaturization, integration, and automation have made microfluidic systems popular. Core to advances in microfluidics are numerous electrophoretic separation and preconcentration strategies, some finding their origins on bench-top systems. Among them, gradient-based strategies are especially effective in addressing sensitivity challenges. This review introduces several gradient-based techniques according to a broad definition, including conductivity, field, and concentration, organized by the method of gradient generation. Each technique is introduced and described, and recent seminal advances explored. View Full-Text
Keywords: gradient; microdevice; electrophoretic separation; preconcentration gradient; microdevice; electrophoretic separation; preconcentration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhu, F.; Hayes, M.A. Exploring Gradients in Electrophoretic Separation and Preconcentration on Miniaturized Devices. Separations 2016, 3, 12.

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