Next Article in Journal
An Integrated Theatre Production for School Nutrition Promotion Program
Previous Article in Journal
The Relationship Between Sleep and Cognition in Children Referred for Neuropsychological Evaluation: A Latent Modeling Approach
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Children 2018, 5(3), 34; doi:10.3390/children5030034

Impact of Supplemental Oxygen on Obstructive Sleep Apnea of Infants

Department of Psychiatry, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Saint Cloud Hospital Sleep Center, CentraCare Health, Saint Cloud, MN 55905, USA
Department of Anesthesiology & Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Multidisciplinary Epidemiological and Translational Research in Intensive Care (M.E.T.R.I.C.), Mayo Clinic, Rochester, MN 55905, USA
Center for Sleep Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Division of Pediatric Neurology and Center for Sleep Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Author to whom correspondence should be addressed.
Received: 28 December 2017 / Revised: 9 February 2018 / Accepted: 21 February 2018 / Published: 2 March 2018
View Full-Text   |   Download PDF [195 KB, uploaded 2 March 2018]


Treatment options may be limited for infants with obstructive sleep apnea when there is no surgically correctable upper airway lesion. We therefore evaluated, retrospectively, the efficacy of low-flow oxygen as a therapeutic option for infant obstructive sleep apnea. We reviewed the medical charts of 23 infants who had undergone a therapeutic trial of low-flow oxygen during polysomnography. Split-night polysomnography was used in 21/23 subjects while 2/23 had undergone two separate, full-night polysomnography sleep architecture and respiratory findings on the baseline polysomnogram segment that was obtained in room air were compared with the segment on low-flow oxygen (0.25–1 L/min). Wilcoxon signed rank or McNemar’s test were used as indicated for comparing apnea hypopnea index and measures of sleep architecture at baseline and with oxygen therapy. The mean (±SD) age of subjects was 4.8 (±2.7) months, with 52% being males. The median apnea hypopnea index fell from a baseline of 18 (range 7–43) to 3 (range 1–19; p = 0.001) on oxygen. The baseline median obstructive/mixed apnea index decreased from 2 (range 1–16) to 1 during oxygen therapy (range 0–1; p = 0.003). Additionally, a significant decrease in central apnea index (median interquartile range (IQR) 1 (0–2) vs. 0 (0–1), p = 0.002) was noted. Sleep efficiency remained unaffected, while O2 saturation (SaO2) average and SaO2 nadir improved on oxygen. We were able to confirm the utility of low-flow oxygen in reducing central, obstructive, and mixed apneas and improving average oxygen saturation in infants with obstructive sleep apnea (OSA). View Full-Text
Keywords: infants; sleep apnea; obstructive; oxygen infants; sleep apnea; obstructive; oxygen
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Das, P.; Kashyap, R.; Kotagal, S. Impact of Supplemental Oxygen on Obstructive Sleep Apnea of Infants. Children 2018, 5, 34.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Children EISSN 2227-9067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top