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Children 2017, 4(6), 49; doi:10.3390/children4060049

The Association between Pediatric NAFLD and Common Genetic Variants

1
Department of Pediatrics, Yale University, 06520, New Haven, CT, USA
2
Dipartimento della Donna, del Bambino, di Vhirurgia Generale e Specialistica, Universita’ della Campania Luigi Vanvitelli, 80138, Napoli, Italy
3
Dipartimento di Medicina V. Tiberio, Universita’ del Molise, 86100, Campobasso, Italy
*
Author to whom correspondence should be addressed.
Received: 31 March 2017 / Revised: 14 June 2017 / Accepted: 15 June 2017 / Published: 18 June 2017
(This article belongs to the Special Issue Pediatric Nonalcoholic Fatty Liver Disease)
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Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of obesity. Several studies have shown that genetic predisposition probably plays an important role in its pathogenesis. In fact, in the last few years a large number of genetic studies have provided compelling evidence that some gene variants, especially those in genes encoding proteins regulating lipid metabolism, are associated with intra-hepatic fat accumulation. Here we provide a comprehensive review of the gene variants that have affected the natural history of the disease. View Full-Text
Keywords: NAFLD; children; genetics NAFLD; children; genetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Umano, G.R.; Martino, M.; Santoro, N. The Association between Pediatric NAFLD and Common Genetic Variants. Children 2017, 4, 49.

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