Next Article in Journal
After the Visit: An Overview of Government and Community Programs Supporting Children with Medical Complexity
Next Article in Special Issue
The Role of Lipid and Lipoprotein Metabolism in Non‐Alcoholic Fatty Liver Disease
Previous Article in Journal
An Evaluation of a Continuing Education Program for Family Caregivers of Ventilator-Dependent Children with Spinal Muscular Atrophy (SMA)
Article Menu

Export Article

Open AccessArticle
Children 2017, 4(5), 34; doi:10.3390/children4050034

Natural History of NAFLD Diagnosed in Childhood: A Single-Center Study

1
Laney Graduate School, Emory University, Atlanta, GA 30322, USA
2
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA
3
Children’s Healthcare of Atlanta, Atlanta, GA 30322, USA
4
Division of Pediatric Surgery, Department of Surgery, School of Medicine, Emory University, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Lucia Pacifico
Received: 13 March 2017 / Revised: 13 April 2017 / Accepted: 26 April 2017 / Published: 3 May 2017
(This article belongs to the Special Issue Pediatric Nonalcoholic Fatty Liver Disease)
View Full-Text   |   Download PDF [1112 KB, uploaded 9 May 2017]   |  

Abstract

Little is known regarding the subsequent course of non-alcoholic fatty liver disease (NAFLD) diagnosed in childhood. The objectives of this single-center study were to gather data on long-term health outcomes and to assess the feasibility of contacting former pediatric patients. In a large pediatric medical center, electronic records were searched to initially identify 162 former patients who had a liver biopsy between 2000 and 2010. Of these, 44 subjects met the criteria for age at follow-up (≥18 year) and biopsy-proven NAFLD, and were recruited via postal and electronic mail. Participants were invited to complete a brief telephone survey on current health status. Supplemental data was also obtained from pediatric medical charts of all subjects. At NAFLD diagnosis, 18% of subjects had diabetes, 91% were obese, 61% had NASH, and 56% had fibrosis on biopsy. At follow-up, 10 subjects (23%) responded to the survey. Based on the survey and chart review, after a mean follow-up of 4.5 years, 5 additional subjects developed diabetes for a period prevalence of 30%, and most subjects (78%) remained obese at last follow-up. Additional prospective studies are needed to fully describe the longitudinal risks associated with pediatric NAFLD, and will require multi-dimensional strategies to successfully recruit former patients. View Full-Text
Keywords: adolescence; BMI; hepatic; metabolic syndrome; longitudinal adolescence; BMI; hepatic; metabolic syndrome; longitudinal
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cioffi, C.E.; Welsh, J.A.; Cleeton, R.L.; Caltharp, S.A.; Romero, R.; Wulkan, M.L.; Konomi, J.V.; Frediani, J.K.; Vos, M.B. Natural History of NAFLD Diagnosed in Childhood: A Single-Center Study. Children 2017, 4, 34.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Children EISSN 2227-9067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top