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Biomedicines 2018, 6(2), 68; https://doi.org/10.3390/biomedicines6020068

HIF Oxygen Sensing Pathways in Lung Biology

1
Research Unit, Hospital of Santa Cristina, Research Institute Princesa (IP), Autonomous University of Madrid, 28009 Madrid, Spain
2
CIBER de Enfermedades Cardiovasculares, Carlos III Health Institute, 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Received: 8 May 2018 / Revised: 28 May 2018 / Accepted: 30 May 2018 / Published: 6 June 2018
(This article belongs to the Special Issue Hypoxia)
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Abstract

Cellular responses to oxygen fluctuations are largely mediated by hypoxia-inducible factors (HIFs). Upon inhalation, the first organ inspired oxygen comes into contact with is the lungs, but the understanding of the pulmonary HIF oxygen-sensing pathway is still limited. In this review we will focus on the role of HIF1α and HIF2α isoforms in lung responses to oxygen insufficiency. In particular, we will discuss novel findings regarding their role in the biology of smooth muscle cells and endothelial cells in the context of hypoxia-induced pulmonary vasoconstriction. Moreover, we will also discuss recent studies into HIF-dependent responses in the airway epithelium, which have been even less studied than the HIF-dependent vascular responses in the lungs. In summary, we will review the biological functions executed by HIF1 or HIF2 in the pulmonary vessels and epithelium to control lung responses to oxygen fluctuations as well as their pathological consequences in the hypoxic lung. View Full-Text
Keywords: lungs; HIF; oxygen; pulmonary hypertension; hypoxia; airway; endothelium; pulmonary smooth muscle cells lungs; HIF; oxygen; pulmonary hypertension; hypoxia; airway; endothelium; pulmonary smooth muscle cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Urrutia, A.A.; Aragonés, J. HIF Oxygen Sensing Pathways in Lung Biology. Biomedicines 2018, 6, 68.

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