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Biomedicines 2018, 6(2), 52; https://doi.org/10.3390/biomedicines6020052

Adiponectin Signaling Pathways in Liver Diseases

Dipartimento di Scienze Biomediche, Sperimentali e Cliniche “Mario Serio”, Università degli Studi di Firenze, Viale Morgagni 50, 50134 Firenze, Italy
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Received: 26 February 2018 / Revised: 26 April 2018 / Accepted: 2 May 2018 / Published: 7 May 2018
(This article belongs to the Special Issue Adiponectin and Its Receptor Interactions in Human Disease)
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Abstract

In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. The binding of adiponectin with its specific receptors induces the activation of a proper signaling cascade that becomes altered in liver pathologies. This review describes the different signaling pathways in healthy and diseased hepatocytes, also highlighting the beneficial role of adiponectin in autophagy activation and hepatic regeneration. View Full-Text
Keywords: adiponectin; liver; signaling pathway adiponectin; liver; signaling pathway
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Gamberi, T.; Magherini, F.; Modesti, A.; Fiaschi, T. Adiponectin Signaling Pathways in Liver Diseases. Biomedicines 2018, 6, 52.

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