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Biomedicines 2018, 6(2), 45; https://doi.org/10.3390/biomedicines6020045

NF-κB, the Importance of Being Dynamic: Role and Insights in Cancer

1
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy
2
Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy
3
Vita-Salute San Raffaele University, 20132 Milan, Italy
*
Authors to whom correspondence should be addressed.
Received: 14 March 2018 / Revised: 11 April 2018 / Accepted: 13 April 2018 / Published: 17 April 2018
(This article belongs to the Special Issue Roles of NF-kB in Cancer and Their Therapeutic Approaches)
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Abstract

In this review, we aim at describing the results obtained in the past years on dynamics features defining NF-κB regulatory functions, as we believe that these developments might have a transformative effect on the way in which NF-κB involvement in cancer is studied. We will also describe technical aspects of the studies performed in this context, including the use of different cellular models, culture conditions, microscopy approaches and quantification of the imaging data, balancing their strengths and limitations and pointing out to common features and to some open questions. Our emphasis in the methodology will allow a critical overview of literature and will show how these cutting-edge approaches can contribute to shed light on the involvement of NF-κB deregulation in tumour onset and progression. We hypothesize that this “dynamic point of view” can be fruitfully applied to untangle the complex relationship between NF-κB and cancer and to find new targets to restrain cancer growth. View Full-Text
Keywords: NF-κB; dynamics; live cell imaging; microfluidics; cancer; transcription NF-κB; dynamics; live cell imaging; microfluidics; cancer; transcription
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Colombo, F.; Zambrano, S.; Agresti, A. NF-κB, the Importance of Being Dynamic: Role and Insights in Cancer. Biomedicines 2018, 6, 45.

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