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Biomedicines 2017, 5(4), 58; doi:10.3390/biomedicines5040058

Innovative Disease Model: Zebrafish as an In Vivo Platform for Intestinal Disorder and Tumors

1
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore
2
School of Pharmacy, National Defense Medical Center, No. 161, Section 6, Minquan East Road, Taipei 114, Taiwan
3
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 13 September 2017 / Revised: 26 September 2017 / Accepted: 29 September 2017 / Published: 29 September 2017
(This article belongs to the Special Issue Cancer Biomarkers and Targets in Digestive Organs)
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Abstract

Colorectal cancer (CRC) is one of the world’s most common cancers and is the second leading cause of cancer deaths, causing more than 50,000 estimated deaths each year. Several risk factors are highly associated with CRC, including being overweight, eating a diet high in red meat and over-processed meat, having a history of inflammatory bowel disease, and smoking. Previous zebrafish studies have demonstrated that multiple oncogenes and tumor suppressor genes can be regulated through genetic or epigenetic alterations. Zebrafish research has also revealed that the activation of carcinogenesis-associated signal pathways plays an important role in CRC. The biology of cancer, intestinal disorders caused by carcinogens, and the morphological patterns of tumors have been found to be highly similar between zebrafish and humans. Therefore, the zebrafish has become an important animal model for translational medical research. Several zebrafish models have been developed to elucidate the characteristics of gastrointestinal diseases. This review article focuses on zebrafish models that have been used to study human intestinal disorders and tumors, including models involving mutant and transgenic fish. We also report on xenograft models and chemically-induced enterocolitis. This review demonstrates that excellent zebrafish models can provide novel insights into the pathogenesis of gastrointestinal diseases and help facilitate the evaluation of novel anti-tumor drugs. View Full-Text
Keywords: colorectal cancer; intestinal disorder; intestinal tumors; zebrafish colorectal cancer; intestinal disorder; intestinal tumors; zebrafish
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lu, J.-W.; Ho, Y.-J.; Ciou, S.-C.; Gong, Z. Innovative Disease Model: Zebrafish as an In Vivo Platform for Intestinal Disorder and Tumors. Biomedicines 2017, 5, 58.

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