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Biomedicines 2017, 5(3), 47; doi:10.3390/biomedicines5030047

Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors

1
Genomic Data Analysis Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel
2
Laboratorio de Endocrinología, Centro de Investigaciones Biológicas del Noroeste, Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz 23096, B.C.S., Mexico
3
Bioinformatics Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 3 July 2017 / Revised: 20 July 2017 / Accepted: 9 August 2017 / Published: 14 August 2017
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Abstract

Widespread microRNA (miRNA) repression is a phenomenon observed in mammals after exposure to cigarette smoke and in many types of cancer. A comprehensive reduction in miRNA expression after treatment with the hormone estrogen has also previously been described. Here, we reveal a conserved association of miRNA downregulation after estrogen exposure in zebrafish, mouse, and human breast cancer cell line, with a high guanine content in the terminal loop sequences of their precursors, and offer a possible link between estrogen-related miRNA-adducts formation and carcinogenesis. We also show common gene expression patterns shared by breast cancer tumors and estrogen-treated zebrafish, suggesting that this organism can be used as a powerful model system for the study of human breast cancer. View Full-Text
Keywords: estrogen; microRNA; Terminal loop; Guanine; cigarette smoke; xenoestrogens; DNA adducts; cancer estrogen; microRNA; Terminal loop; Guanine; cigarette smoke; xenoestrogens; DNA adducts; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cohen, A.; Burgos-Aceves, M.A.; Kahan, T.; Smith, Y. Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors. Biomedicines 2017, 5, 47.

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