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Biomedicines 2016, 4(3), 22; doi:10.3390/biomedicines4030022

An Abraded Surface of Doxorubicin-Loaded Surfactant-Containing Drug Delivery Systems Effectively Reduces the Survival of Carcinoma Cells

Department of Biomaterials and Healthcare, Division of Life Science and Bioprocesses, Fraunhofer Institute for Applied Polymer Research (IAP), Geiselbergstraße 69, 14476 Potsdam-Golm, Germany
Institute of Materials and Energy, Helmholtz-Center Berlin, Hahn-Meitner-Platz 1, 14109 Berlin, Germany
Department of Pharmaceutical Engineering, Beuth University of Applied Sciences Berlin, 13353 Berlin, Germany
Instituto de Pesquisas Energéticas e Nucleares, Avenida Lineo Prestes, 2342, Cidade Universitária Armando Salles de Oliveira, SP 05508-900, Brazil
School of Chemical Engineering, University of Campinas, Campinas, SP 13083-970, Brazil
Department of Clinical Sciences, Cell and Molecular Biology Program and Flint Cancer Center, Colorado State University, Fort Collins, CO 80523-1052, USA
Instituto de Química, Campinas, Universidade Estadual de Campinas, Campinas, SP 13083-970, Brazil
Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP 09210-580, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Shaker A. Mousa
Received: 27 July 2016 / Revised: 7 September 2016 / Accepted: 12 September 2016 / Published: 15 September 2016
(This article belongs to the Section Tumor Immunology and Immunotherapy)
View Full-Text   |   Download PDF [2077 KB, uploaded 15 September 2016]   |  


An effective antitumor remedy is yet to be developed. All previous approaches for a targeted delivery of anticancer medicine have relied on trial and error. The goal of this study was to use structural insights gained from the study of delivery systems and malignant cells to provide for a systematic approach to the development of next-generation drugs. We used doxorubicin (Dox) liposomal formulations. We assayed for cytotoxicity via the electrical current exclusion method. Dialysis of the samples yielded information about their drug release profiles. Information about the surface of the delivery systems was obtained through synchrotron small-angle X-ray scattering (SAXS) measurements. SAXS measurements revealed that Dox-loading yielded an abraded surface of our Dox liposomal formulation containing soybean oil, which also correlated with an effective reduction of the survival of carcinoma cells. Furthermore, a dialysis assay revealed that a higher burst of Dox was released from soybean oil-containing preparations within the first five hours. We conclude from our results that an abraded surface of Dox-loaded drug delivery system increases their efficacy. The apparent match between surface geometry of drug delivery systems and target cells is suggested as a steppingstone for refined development of drug delivery systems. This is the first study to provide a systematic approach to developing next-generation drug carrier systems using structural insights to guide the development of next-generation drug delivery systems with increased efficacy and reduced side effects. View Full-Text
Keywords: drug delivery; doxorubicin; cancer therapy; synchrotron small-angle X-ray scattering; in vitro tests drug delivery; doxorubicin; cancer therapy; synchrotron small-angle X-ray scattering; in vitro tests

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Schmidt, C.; Yokaichiya, F.; Doğangüzel, N.; Dias Franco, M.K.K.; Cavalcanti, L.P.; Brown, M.A.; Alkschbirs, M.I.; de Araujo, D.R.; Kumpugdee-Vollrath, M.; Storsberg, J. An Abraded Surface of Doxorubicin-Loaded Surfactant-Containing Drug Delivery Systems Effectively Reduces the Survival of Carcinoma Cells. Biomedicines 2016, 4, 22.

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