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Biomedicines 2015, 3(3), 248-269; doi:10.3390/biomedicines3030248

Aptamers and Their Significant Role in Cancer Therapy and Diagnosis

Faculty of Allied Health Sciences (FAHS), Chettinad Academy of Research and Education, Kelambakkam, Chennai 603103, Tamil Nadu, India
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Author to whom correspondence should be addressed.
Academic Editor: Kenneth Cornetta
Received: 3 June 2015 / Accepted: 7 August 2015 / Published: 1 September 2015
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Abstract

Aptamers are nucleic acid/peptide molecules that can be generated by a sophisticated, well-established technique known as Systematic Evolution of Ligands by EXponential enrichment (SELEX). Aptamers can interact with their targets through structural recognition, as in antibodies, though with higher specificity. With this added advantage, they can be made useful for clinical applications such as targeted therapy and diagnosis. In this review, we have discussed the steps involved in SELEX process and modifications executed to attain high affinity nucleic acid aptamers. Moreover, our review also highlights the therapeutic applications of aptamer functionalized nanoparticles and nucleic acids as chemo-therapeutic agents. In addition, we have described the development of “aptasensor” in clinical diagnostic application for detecting cancer cells and the use of aptamers in different routine imaging techniques, such as Positron Emission Tomography/Computed Tomography, Ultrasound, and Magnetic Resonance Imaging. View Full-Text
Keywords: aptamers; SELEX (Systematic Evolution of Ligands by EXponential enrichment); cell surface biomarkers; nanoparticles; aptasensors; cancer imaging aptamers; SELEX (Systematic Evolution of Ligands by EXponential enrichment); cell surface biomarkers; nanoparticles; aptasensors; cancer imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Prakash, J.S.; Rajamanickam, K. Aptamers and Their Significant Role in Cancer Therapy and Diagnosis. Biomedicines 2015, 3, 248-269.

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