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Chemosensors 2016, 4(3), 13; doi:10.3390/chemosensors4030013

Guanine Quadruplex Electrochemical Aptasensors

Department of Chemistry, Faculty of Science and Technology, University of Coimbra, 3004-535 Coimbra, Portugal
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Author to whom correspondence should be addressed.
Academic Editors: Paolo Ugo and Ligia Moretto
Received: 9 May 2016 / Revised: 14 July 2016 / Accepted: 26 July 2016 / Published: 30 July 2016
(This article belongs to the Special Issue Electrochemical Immunosensors and Aptasensors)
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Abstract

Guanine-rich nucleic acids are able to self-assemble into G-quadruplex four-stranded secondary structures, which are found at the level of telomeric regions of chromosomes, oncogene promoter sequences and other biologically-relevant regions of the genome. Due to their extraordinary stiffness and biological role, G-quadruples become relevant in areas ranging from structural biology to medicinal chemistry, supra-molecular chemistry, nanotechnology and biosensor technology. In addition to classical methodologies, such as circular dichroism, nuclear magnetic resonance or crystallography, electrochemical methods have been successfully used for the rapid detection of the conformational changes from single-strand to G-quadruplex. This review presents recent advances on the G-quadruplex electrochemical characterization and on the design and applications of G-quadruplex electrochemical biosensors, with special emphasis on the G-quadruplex aptasensors and hemin/G-quadruplex peroxidase-mimicking DNAzyme biosensors. View Full-Text
Keywords: G-quadruplex; G4; GQ; aptasensor; DNAzyme; DNA electrochemical biosensor G-quadruplex; G4; GQ; aptasensor; DNAzyme; DNA electrochemical biosensor
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Chiorcea-Paquim, A.-M.; Oliveira-Brett, A.M. Guanine Quadruplex Electrochemical Aptasensors. Chemosensors 2016, 4, 13.

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