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Chemosensors 2016, 4(2), 9; doi:10.3390/chemosensors4020009

A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions

Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Academic Editor: Igor Medintz
Received: 14 December 2015 / Revised: 3 April 2016 / Accepted: 3 April 2016 / Published: 4 May 2016
View Full-Text   |   Download PDF [172 KB, uploaded 4 May 2016]

Abstract

Strontium-82 is produced by proton activation of a rubidium chloride target in an accelerator or cyclotron and purified by ion exchange chromatography. The Strontrium-82 is used in Cardigen generators to produce Rubidium-82 for cardiac imaging. Quality control testing of the purified Strontium-82 is performed with Inductively Coupled Plasma-Optical Emission spectroscopy (ICP-OES) and gamma spectroscopy. To meet Department of Energy specifications for HCl molarity the purified Strontium-82 solution needs to be tested to determine if the isotope is in the 0.05–0.5 M HCl range. This manuscript reports a simple HCl molarity test to determine if the purified Strontium-82 solution meets specifications. Validation of the assay was performed by evaluating all solutions associate with Strontium-82 processing. View Full-Text
Keywords: molarity test; quality control; strontium-82; Sr-82; BromoCresol Purple molarity test; quality control; strontium-82; Sr-82; BromoCresol Purple
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fitzsimmons, J. A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions. Chemosensors 2016, 4, 9.

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