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Healthcare 2017, 5(1), 5; doi:10.3390/healthcare5010005

The Role of Lipid Biomarkers in Major Depression

Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King’s College London, 125 Coldharbour Lane, London SE5 9NU, UK
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Academic Editor: Sampath Parthasarathy
Received: 28 October 2016 / Revised: 20 January 2017 / Accepted: 23 January 2017 / Published: 3 February 2017
(This article belongs to the Special Issue Diet Quality)
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Abstract

In the UK, the lifetime-documented prevalence of major depressive disorder (MDD) is currently 10%. Despite its increasing prevalence and devastating impact on quality of life, the pathophysiological mechanisms underpinning MDD remain to be fully elucidated. Current theories of neurobiological components remain incomplete and protein-centric, rendering pharmacological treatment options suboptimal. In this review, we highlight the pivotal role of lipids in intra- and inter-neuronal functioning, emphasising the potential use of lipids as biomarkers for MDD. The latter has significant implications for improving our understanding of MDD at the cellular and circuit level. There is particular focus on cholesterol (high and low density lipoprotein), omega-3, and omega-6 polyunsaturated fatty acids due to established evidence in the literature of a link between atherosclerotic disease and major depression. We argue that there is significant potential scope for the use of such peripheral biomarkers in the diagnosis, stratification and treatment of MDD. View Full-Text
Keywords: lipid biomarkers; major depressive disorder; cholesterol; polyunsaturated fatty acids lipid biomarkers; major depressive disorder; cholesterol; polyunsaturated fatty acids
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Parekh, A.; Smeeth, D.; Milner, Y.; Thuret, S. The Role of Lipid Biomarkers in Major Depression. Healthcare 2017, 5, 5.

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