Next Article in Journal / Special Issue
Regional Diversity in the Postsynaptic Proteome of the Mouse Brain
Previous Article in Journal
Proteomic Analysis of Histone Variants and Their PTMs: Strategies and Pitfalls
Article Menu

Export Article

Open AccessFeature PaperReview
Proteomes 2018, 6(3), 30; https://doi.org/10.3390/proteomes6030030

Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders

Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Angus C. Nairn and Kenneth R. Williams
Received: 2 June 2018 / Revised: 10 July 2018 / Accepted: 13 July 2018 / Published: 19 July 2018
(This article belongs to the Special Issue Neuroproteomics)
Full-Text   |   PDF [2441 KB, uploaded 19 July 2018]   |  

Abstract

The mammalian nervous system is an immensely heterogeneous organ composed of a diverse collection of neuronal types that interconnect in complex patterns. Synapses are highly specialized neuronal cell-cell junctions with common and distinct functional characteristics that are governed by their protein composition or synaptic proteomes. Even a single neuron can possess a wide-range of different synapse types and each synapse contains hundreds or even thousands of proteins. Many neurological disorders and diseases are caused by synaptic dysfunction within discrete neuronal populations. Mass spectrometry (MS)-based proteomic analysis has emerged as a powerful strategy to characterize synaptic proteomes and potentially identify disease driving synaptic alterations. However, most traditional synaptic proteomic analyses have been limited by molecular averaging of proteins from multiple types of neurons and synapses. Recently, several new strategies have emerged to tackle the ‘averaging problem’. In this review, we summarize recent advancements in our ability to characterize neuron-type specific and synapse-type specific proteomes and discuss strengths and limitations of these emerging analysis strategies. View Full-Text
Keywords: proteomics; basal ganglia; synapses; synapse specificity; neuronal circuits; axons; dendrites; neurodegeneration proteomics; basal ganglia; synapses; synapse specificity; neuronal circuits; axons; dendrites; neurodegeneration
Figures

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Wang, Y.-Z.; Savas, J.N. Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders. Proteomes 2018, 6, 30.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Proteomes EISSN 2227-7382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top