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Proteomes 2018, 6(2), 26; https://doi.org/10.3390/proteomes6020026

Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect

1
Department of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282004, India
2
Medical Microbiology and Molecular Biology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
*
Authors to whom correspondence should be addressed.
Received: 4 May 2018 / Revised: 24 May 2018 / Accepted: 26 May 2018 / Published: 28 May 2018
(This article belongs to the Special Issue Clinical Proteomics 2018)
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Abstract

Mycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug resistance but some resistance mechanisms are still unknown. Recently approved line probe assay (LPA) diagnostics for detecting the resistance to first and second line drugs are unable to diagnose the drug resistance in M. tuberculosis isolates which do not have the mutations in particular genes responsible for resistance. Proteomics and bioinformatic tools emerged as direct approaches for identification and characterization of novel proteins which are directly and indirectly involved in drug resistance that could be used as potential targets in future. In future, these novel targets might reveal new mechanism of resistance and can be used in diagnostics or as drug targets. View Full-Text
Keywords: tuberculosis; infectious diseases; drug resistance; proteomics; alternative strategies tuberculosis; infectious diseases; drug resistance; proteomics; alternative strategies
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Sharma, D.; Bisht, D.; Khan, A.U. Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect. Proteomes 2018, 6, 26.

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