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Proteomes 2018, 6(2), 17; https://doi.org/10.3390/proteomes6020017

Molecular Pathophysiology of Epithelial Barrier Dysfunction in Inflammatory Bowel Diseases

1
School of Medical Sciences, Faculty of Medicine, The University of New South Wales, Sydney 2052, NSW, Australia
2
Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney 2052, NSW, Australia
3
South West Sydney Clinical School, Faculty of Medicine, The University of New South Wales, Sydney 2052, NSW, Australia
4
Department of Gastroenterology, Concord Repatriation General Hospital, Sydney 2139, NSW, Australia
5
Translational Medicine and Early Clinical, Takeda Pharmaceuticals, Cambridge, MA 02139, USA
6
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
*
Author to whom correspondence should be addressed.
Received: 11 January 2018 / Revised: 24 March 2018 / Accepted: 26 March 2018 / Published: 31 March 2018
(This article belongs to the Special Issue Proteomic Biomarkers in Human Diseases)
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Abstract

Over the years, the scientific community has explored myriads of theories in search of the etiology and a cure for inflammatory bowel disease (IBD). The cumulative evidence has pointed to the key role of the intestinal barrier and the breakdown of these mechanisms in IBD. More and more scientists and clinicians are embracing the concept of the impaired intestinal epithelial barrier and its role in the pathogenesis and natural history of IBD. However, we are missing a key tool that bridges these scientific insights to clinical practice. Our goal is to overcome the limitations in understanding the molecular physiology of intestinal barrier function and develop a clinical tool to assess and quantify it. This review article explores the proteins in the intestinal tissue that are pivotal in regulating intestinal permeability. Understanding the molecular pathophysiology of impaired intestinal barrier function in IBD may lead to the development of a biochemical method of assessing intestinal tissue integrity which will have a significant impact on the development of novel therapies targeting the intestinal mucosa. View Full-Text
Keywords: intestinal barrier function; inflammatory bowel disease intestinal barrier function; inflammatory bowel disease
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Lee, J.Y.; Wasinger, V.C.; Yau, Y.Y.; Chuang, E.; Yajnik, V.; Leong, R.W. Molecular Pathophysiology of Epithelial Barrier Dysfunction in Inflammatory Bowel Diseases. Proteomes 2018, 6, 17.

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