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Proteomes 2018, 6(1), 12; doi:10.3390/proteomes6010012

The Gene-Centric Content Management System and Its Application for Cognitive Proteomics

Orekhovich Institute of Biomedical Chemistry, Moscow 119191, Russia
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Received: 31 December 2017 / Revised: 7 February 2018 / Accepted: 20 February 2018 / Published: 23 February 2018
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Abstract

The Human Proteome Project is moving into the next phase of creating and/or reconsidering the functional annotations of proteins using the chromosome-centric paradigm. This challenge cannot be solved exclusively using automated means, but rather requires human intelligence for interpreting the combined data. To foster the integration between human cognition and post-genome array a number of specific tools were recently developed, among them CAPER, GenomewidePDB, and The Proteome Browser (TPB). For the purpose of tackling the task of protein functional annotating the Gene-Centric Content Management System (GenoCMS) was expanded with new features. The goal was to enable bioinformaticans to develop self-made applications and to position these applets within the generalized informational canvas supported by GenoCMS. We report the results of GenoCMS-enabled integration of the concordant informational flows in the chromosome-centric framework of the human chromosome 18 project. The workflow described in the article can be scaled to other human chromosomes, and also supplemented with new tracks created by the user. The GenoCMS is an example of a project-oriented informational system, which are important for public data sharing. View Full-Text
Keywords: knowledge base; data-enabled science; integrative biology; Omics science; Human Proteome Project; chromosome 18 knowledge base; data-enabled science; integrative biology; Omics science; Human Proteome Project; chromosome 18
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Poverennaya, E.V.; Shargunov, A.V.; Ponomarenko, E.A.; Lisitsa, A.V. The Gene-Centric Content Management System and Its Application for Cognitive Proteomics. Proteomes 2018, 6, 12.

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