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Plants 2013, 2(3), 371-378; doi:10.3390/plants2030371

In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines

Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Str. Radoja Domanovića No. 12, 34000 Kragujevac, Republic of Serbia
Department of Biomedical Sciences, State University of Novi Pazar, Vuka Karadzica, 36300 Novi Pazar, Republic of Serbia
Author to whom correspondence should be addressed.
Received: 6 April 2013 / Revised: 16 May 2013 / Accepted: 6 June 2013 / Published: 25 June 2013
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In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 and MDA-MB-231 cell line in vitro. In order to determine the cytotoxic effects we used an MTT viability assay. The results showed that cell growth is significantly lower in extract treated cells compared to untreated control. The effect of inhibition of cell growth was higher in the treatment of HCT-116 cell line than in MDA-MB-231. Based on the results it is determined that O. vulgare is a significant source of biologically active substances that have cytotoxic and antiproliferative activity in vitro. View Full-Text
Keywords: antiproliferative activity; HCT-116; MDA-MB-231; Origanum vulgare L. antiproliferative activity; HCT-116; MDA-MB-231; Origanum vulgare L.

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Grbović, F.; Stanković, M.S.; Ćurčić, M.; Đorđević, N.; Šeklić, D.; Topuzović, M.; Marković, S. In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines. Plants 2013, 2, 371-378.

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