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In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines
Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Str. Radoja Domanovića No. 12, 34000 Kragujevac, Republic of Serbia
Department of Biomedical Sciences, State University of Novi Pazar, Vuka Karadzica, 36300 Novi Pazar, Republic of Serbia
* Author to whom correspondence should be addressed.
Received: 6 April 2013; in revised form: 16 May 2013 / Accepted: 6 June 2013 / Published: 25 June 2013
Abstract: In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 and MDA-MB-231 cell line in vitro. In order to determine the cytotoxic effects we used an MTT viability assay. The results showed that cell growth is significantly lower in extract treated cells compared to untreated control. The effect of inhibition of cell growth was higher in the treatment of HCT-116 cell line than in MDA-MB-231. Based on the results it is determined that O. vulgare is a significant source of biologically active substances that have cytotoxic and antiproliferative activity in vitro.
Keywords: antiproliferative activity; HCT-116; MDA-MB-231; Origanum vulgare L.
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Grbović, F.; Stanković, M.S.; Ćurčić, M.; Đorđević, N.; Šeklić, D.; Topuzović, M.; Marković, S. In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines. Plants 2013, 2, 371-378.
Grbović F, Stanković MS, Ćurčić M, Đorđević N, Šeklić D, Topuzović M, Marković S. In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines. Plants. 2013; 2(3):371-378.
Grbović, Filip; Stanković, Milan S.; Ćurčić, Milena; Đorđević, Nataša; Šeklić, Dragana; Topuzović, Marina; Marković, Snežana. 2013. "In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines." Plants 2, no. 3: 371-378.